[HTML][HTML] Defective hepatic regeneration after partial hepatectomy in leptin-deficient mice is not rescued by exogenous leptin
IA Leclercq, M Vansteenberghe, VB Lebrun… - Laboratory …, 2006 - Elsevier
Liver regeneration after partial hepatectomy (PH) is impaired in leptin-deficient ob/ob mice.
Here, we tested whether exogenous leptin and/or correction of the obese phenotype (by
food restriction or long-term leptin administration) would rescue hepatocyte proliferation and
whether the hepatic progenitor cell compartment was activated in leptin-deficient ob/ob
livers after PH. Because of the high mortality following 70% PH to ob/ob mice, we performed
a less extensive (55%) resection. Compared to lean mice, liver regeneration after 55% PH …
Here, we tested whether exogenous leptin and/or correction of the obese phenotype (by
food restriction or long-term leptin administration) would rescue hepatocyte proliferation and
whether the hepatic progenitor cell compartment was activated in leptin-deficient ob/ob
livers after PH. Because of the high mortality following 70% PH to ob/ob mice, we performed
a less extensive (55%) resection. Compared to lean mice, liver regeneration after 55% PH …