Targeting the epigenome for treatment of cancer
EJ Geutjes, PK Bajpe, R Bernards - Oncogene, 2012 - nature.com
EJ Geutjes, PK Bajpe, R Bernards
Oncogene, 2012•nature.comCancer genome analyses have revealed that the enzymes involved in epigenetic gene
regulation are frequently deregulated in cancer. Here we describe the enzymes that control
the epigenetic state of the cell, how they are affected in cancer and how this knowledge can
be exploited to treat cancer with a new arsenal of selective therapies.
regulation are frequently deregulated in cancer. Here we describe the enzymes that control
the epigenetic state of the cell, how they are affected in cancer and how this knowledge can
be exploited to treat cancer with a new arsenal of selective therapies.
Abstract
Cancer genome analyses have revealed that the enzymes involved in epigenetic gene regulation are frequently deregulated in cancer. Here we describe the enzymes that control the epigenetic state of the cell, how they are affected in cancer and how this knowledge can be exploited to treat cancer with a new arsenal of selective therapies.
nature.com
