Plasma contact system activation drives anaphylaxis in severe mast cell–mediated allergic reactions
A Sala-Cunill, J Björkqvist, R Senter, M Guilarte… - Journal of Allergy and …, 2015 - Elsevier
Background Anaphylaxis is an acute, potentially lethal, multisystem syndrome resulting from
the sudden release of mast cell–derived mediators into the circulation. Objectives and
Methods We report here that a plasma protease cascade, the factor XII–driven contact
system, critically contributes to the pathogenesis of anaphylaxis in both murine models and
human subjects. Results Deficiency in or pharmacologic inhibition of factor XII, plasma
kallikrein, high-molecular-weight kininogen, or the bradykinin B2 receptor, but not the B1 …
the sudden release of mast cell–derived mediators into the circulation. Objectives and
Methods We report here that a plasma protease cascade, the factor XII–driven contact
system, critically contributes to the pathogenesis of anaphylaxis in both murine models and
human subjects. Results Deficiency in or pharmacologic inhibition of factor XII, plasma
kallikrein, high-molecular-weight kininogen, or the bradykinin B2 receptor, but not the B1 …