A new era for an ancient drug: arsenic trioxide and Hedgehog signaling
EM Beauchamp, A Üren - Vitamins & Hormones, 2012 - Elsevier
Arsenic has been used for ages as a therapeutic agent. Currently, it is an FDA approved
drug to treat acute promyelocytic leukemia where it leads to degradation of the PML–RAR
fusion protein. It has been shown to have various other targets in cells such as JNK, NFκB,
thioredoxin reductase, and MAPK pathways. Most of its effects in cells have been through
arsenic's ability to bind to thiol groups in cysteine residues. Recent evidence has shown that
arsenic can inhibit the Hedgehog pathway by inhibiting GLI proteins. The proposed …
drug to treat acute promyelocytic leukemia where it leads to degradation of the PML–RAR
fusion protein. It has been shown to have various other targets in cells such as JNK, NFκB,
thioredoxin reductase, and MAPK pathways. Most of its effects in cells have been through
arsenic's ability to bind to thiol groups in cysteine residues. Recent evidence has shown that
arsenic can inhibit the Hedgehog pathway by inhibiting GLI proteins. The proposed …