Zebrafish larvae provide models of muscle development, muscle disease and muscle-
related chemical toxicity, but related studies often lack functional measures of muscle health.
In this video article, we demonstrate a method to measure force generation during
contraction of zebrafish larval trunk muscle. Force measurements are accomplished by
placing an anesthetized larva into a chamber filled with a salt solution. The anterior end of
the larva is tied to a force transducer and the posterior end of the larva is tied to a length …