Proteolysis within the cardiac sarcomere is a constantly evolving area of research. Three
major pathways of proteolysis have been identified as being active within the cardiac
sarcomere, namely the ubiquitin-proteasome system, autophagy, and the calpain system.
The role of ubiquitin-proteasome system-mediated proteolysis in cardiovascular health and
disease has been known for some time; however, it is now apparent that other proteolytic
systems also aid in the stabilization of cardiac sarcomere structure and function. This …