[HTML][HTML] Tensin1 requires protein phosphatase-1α in addition to RhoGAP DLC-1 to control cell polarization, migration, and invasion
EH Hall, AE Daugherty, CK Choi, AF Horwitz… - Journal of biological …, 2009 - ASBMB
Tensin is a family of multidomain scaffold proteins that bind the cytoplasmic tail of β-integrins
and localize to adhesions that anchor stress fibers in cells. Tensin expression is suppressed
in cancer, especially metastatic cancer. The N-terminal domain of tensin1 associates with
protein phosphatase-1α (PP1α) and mediates PP1α localization to adhesions. Here, we
show F302A mutation in a KVXF motif of tensin1 abrogates binding to PP1α. The SH2
domain in tensin family member c-ten requires R474 to bind a RhoGAP called DLC-1 …
and localize to adhesions that anchor stress fibers in cells. Tensin expression is suppressed
in cancer, especially metastatic cancer. The N-terminal domain of tensin1 associates with
protein phosphatase-1α (PP1α) and mediates PP1α localization to adhesions. Here, we
show F302A mutation in a KVXF motif of tensin1 abrogates binding to PP1α. The SH2
domain in tensin family member c-ten requires R474 to bind a RhoGAP called DLC-1 …
