[HTML][HTML] Aberrant epigenetic and genetic marks are seen in myelodysplastic leukocytes and reveal Dock4 as a candidate pathogenic gene on chromosome 7q
L Zhou, J Opalinska, D Sohal, Y Yu, Y Mo… - Journal of Biological …, 2011 - ASBMB
Myelodysplastic syndromes (MDS) are characterized by abnormal and dysplastic maturation
of all blood lineages. Even though epigenetic alterations have been seen in MDS marrow
progenitors, very little is known about the molecular alterations in dysplastic peripheral
blood cells. We analyzed the methylome of MDS leukocytes by the HELP assay and
determined that it was globally distinct from age-matched controls and was characterized by
numerous novel, aberrant hypermethylated marks that were located mainly outside of CpG …
of all blood lineages. Even though epigenetic alterations have been seen in MDS marrow
progenitors, very little is known about the molecular alterations in dysplastic peripheral
blood cells. We analyzed the methylome of MDS leukocytes by the HELP assay and
determined that it was globally distinct from age-matched controls and was characterized by
numerous novel, aberrant hypermethylated marks that were located mainly outside of CpG …
