Longitudinal studies of the neurobiology of vitamin E and other antioxidant systems, and neurological function in the vitamin E deficient rat
MA Goss-Sampson, CJ MacEvilly… - Journal of the neurological …, 1988 - Elsevier
Longitudinal studies were carried out over 55 weeks in vitamin E deficient and control rats. It
was shown that neurological tissues (brain, cord and nerve) retained a greater percentage
of vitamin E (α-tocopherol) than other tissues (serum, liver and adipose tissue), and that
there was no evidence for compensation by other antioxidant enzyme systems (superoxide
dismutase and glutathione peroxidase). An increased uptake of α-[3 H] tocopherol (150% of
controls) was observed in peripheral nerve of deficient animals from 11 weeks, whereas …
was shown that neurological tissues (brain, cord and nerve) retained a greater percentage
of vitamin E (α-tocopherol) than other tissues (serum, liver and adipose tissue), and that
there was no evidence for compensation by other antioxidant enzyme systems (superoxide
dismutase and glutathione peroxidase). An increased uptake of α-[3 H] tocopherol (150% of
controls) was observed in peripheral nerve of deficient animals from 11 weeks, whereas …
