Human sepsis is characterized by a set of systemic reactions in response to intensive and
massive infection that failed to be locally contained by the host. Currently, sepsis ranks
among the top ten causes of mortality in the USA intensive care units 1. During sepsis there
are two established haemodynamic phases that may overlap. The initial phase
(hyperdynamic) is defined as a massive production of proinflammatory cytokines and
reactive oxygen species by macrophages and neutrophils that affects vascular permeability …