This paper reviews the evidence that salt sensitivity of blood pressure is related both to the
anion ingested with sodium as well as to other components of the diet. In several
experimental models of salt-sensitive hypertension and in humans, blood pressure is not
increased by a high sodium intake provided with anions other than chloride. Salt-induced
increase of blood pressure depends on the concomitant ingestion of both sodium and
chloride. Both epidemiologic and clinical evidence suggest that sodium chloride-induced …