[HTML][HTML] Phospholipase Cγ2 provides survival signals via Bcl2 and A1 in different subpopulations of B cells
R Wen, Y Chen, L Xue, J Schuman, S Yang… - Journal of Biological …, 2003 - ASBMB
PLCγ2 plays a critical role in B cell receptor (BCR) signaling and its targeted deletion results
in defective B cell development and function. Here, we show that PLCγ2 deficiency
specifically blocks B cell maturation at the transitional type 2 (T2) to follicular (FO) B cell
transition and the PLCγ2 pathway regulates survival of B cells. BCR-induced apoptosis is
dramatically enhanced in all subsets of splenic PLCγ2-deficient B cells, especially in T2 and
FO B cell subpopulations. We also find that all splenic PLCγ2-deficient B cell subpopulations …
in defective B cell development and function. Here, we show that PLCγ2 deficiency
specifically blocks B cell maturation at the transitional type 2 (T2) to follicular (FO) B cell
transition and the PLCγ2 pathway regulates survival of B cells. BCR-induced apoptosis is
dramatically enhanced in all subsets of splenic PLCγ2-deficient B cells, especially in T2 and
FO B cell subpopulations. We also find that all splenic PLCγ2-deficient B cell subpopulations …