Cetirizine: a pharmacokinetic and pharmacodynamic evaluation in children with seasonal allergic rhinitis
WTA Watson, KJ Simons, XY Chen… - Journal of allergy and …, 1989 - Elsevier
In a double-blind, randomized, parallel-group 5-week study, cetirizine, 5 mg or 10 mg daily,
was ingested by 10 and nine children, respectively. Cetirizine was rapidly absorbed with
mean peak cetirizine concentrations of 427.6±SD, 144.2 ng/ml. 1.4±1.1 hours after the 5 mg
dose, and 978.4±340.6 ng/ml, 0.8±0.4 hours after the 10 mg dose. The dose-independent
serum-elimination half-life of cetirizine was 7.1±1.6 hours after cetirizine, 5 mg, and 69±1.6
hours after cetirizine, 10 mg. Urinary excretion of unchanged cetirizine during 24 hours after …
was ingested by 10 and nine children, respectively. Cetirizine was rapidly absorbed with
mean peak cetirizine concentrations of 427.6±SD, 144.2 ng/ml. 1.4±1.1 hours after the 5 mg
dose, and 978.4±340.6 ng/ml, 0.8±0.4 hours after the 10 mg dose. The dose-independent
serum-elimination half-life of cetirizine was 7.1±1.6 hours after cetirizine, 5 mg, and 69±1.6
hours after cetirizine, 10 mg. Urinary excretion of unchanged cetirizine during 24 hours after …