[HTML][HTML] Use of the Pharmacological Inhibitor BX795 to Study the Regulation and Physiological Roles of TBK1 and IκB Kinase ϵ: a distinct upstream kinase mediates …
TANK-binding kinase 1 (TBK1) and IκB kinase ϵ (IKKϵ) regulate the production of Type 1
interferons during bacterial and viral infection, but the lack of useful pharmacological
inhibitors has hampered progress in identifying additional physiological roles of these
protein kinases and how they are regulated. Here we demonstrate that BX795, a potent and
relatively specific inhibitor of TBK1 and IKKϵ, blocked the phosphorylation, nuclear
translocation, and transcriptional activity of interferon regulatory factor 3 and, hence, the …
interferons during bacterial and viral infection, but the lack of useful pharmacological
inhibitors has hampered progress in identifying additional physiological roles of these
protein kinases and how they are regulated. Here we demonstrate that BX795, a potent and
relatively specific inhibitor of TBK1 and IKKϵ, blocked the phosphorylation, nuclear
translocation, and transcriptional activity of interferon regulatory factor 3 and, hence, the …