Inhibition of clathrin/dynamin-dependent internalization interferes with LPS-mediated TRAM–TRIF-dependent signaling pathway
Y Wang, Y Yang, X Liu, N Wang, H Cao, Y Lu… - Cellular …, 2012 - Elsevier
Recognition of lipopolysaccharide (LPS) by Toll-like receptor 4 (TLR4) activates two district
proinflammatory signaling pathway and initiates LPS internalization. To investigate roles of
LPS internalization, a traditionally regarded metabolic pathway for LPS, in regulation of
these two pathways, three internalization inhibitors, monodansylcadaverine (MDC, a clathrin
inhibitor), dynasore (DS, a dynamin inhibitor) and chloroquine (CQ, an endosome acidifying
maturation inhibitor) were applied to induce internalization dysfunction in macrophages …
proinflammatory signaling pathway and initiates LPS internalization. To investigate roles of
LPS internalization, a traditionally regarded metabolic pathway for LPS, in regulation of
these two pathways, three internalization inhibitors, monodansylcadaverine (MDC, a clathrin
inhibitor), dynasore (DS, a dynamin inhibitor) and chloroquine (CQ, an endosome acidifying
maturation inhibitor) were applied to induce internalization dysfunction in macrophages …