[HTML][HTML] Diet-induced obese mice have increased mortality and altered immune responses when infected with influenza virus
AG Smith, PA Sheridan, JB Harp, MA Beck - The Journal of nutrition, 2007 - Elsevier
Obesity is associated with an impaired immune response, an increased susceptibility to
bacterial infection, and a chronic increase in proinflammatory cytokines such as IL-6 and
TNFα. However, few studies have examined the effect of obesity on the immune response to
viral infections. Because infection with influenza is a leading cause of morbidity and mortality
worldwide, we investigated the effect of obesity on early immune responses to influenza
virus exposure. Diet-induced obese and lean control C57BL/6 mice were infected with …
bacterial infection, and a chronic increase in proinflammatory cytokines such as IL-6 and
TNFα. However, few studies have examined the effect of obesity on the immune response to
viral infections. Because infection with influenza is a leading cause of morbidity and mortality
worldwide, we investigated the effect of obesity on early immune responses to influenza
virus exposure. Diet-induced obese and lean control C57BL/6 mice were infected with …