Thrombin modulation of natural killer activity in human peripheral lymphocytes
A Naldini, DH Carney - Cellular immunology, 1996 - Elsevier
In addition to its pivotal role in the coagulation cascade, thrombin is mitogenic for fibroblasts
and endothelial cells, and activates a number of inflammatory cells including monocytes and
T-lymphocytes. To determine if other immune functions are modulated by thrombin and if this
modulation is direct or indirect, we investigated whether highly purified human α-thrombin
affects natural killer (NK) and lymphokine-activated killer (LAK) cell-mediated cytotoxicity.
Thrombin enhanced NK cell-mediated cytotoxicity by more than 60% and enhanced IL-2 …
and endothelial cells, and activates a number of inflammatory cells including monocytes and
T-lymphocytes. To determine if other immune functions are modulated by thrombin and if this
modulation is direct or indirect, we investigated whether highly purified human α-thrombin
affects natural killer (NK) and lymphokine-activated killer (LAK) cell-mediated cytotoxicity.
Thrombin enhanced NK cell-mediated cytotoxicity by more than 60% and enhanced IL-2 …