[HTML][HTML] The contribution of PARs to inflammation and immunity to fungi
S Moretti, S Bellocchio, P Bonifazi, S Bozza… - Mucosal …, 2008 - Elsevier
During inflammation, host-and microbial-derived proteases trigger the activation of protease-
activated receptors (PARs), a family of G-protein-coupled receptors. We report here that
activation of Toll-like receptors (TLRs) by fungi unmasks an essential and divergent role for
PAR 1 and PAR 2 in downstream signaling and inflammation. TLRs activated PARs and
triggered distinct signal transduction pathways involved in inflammation and immunity to
Candida albicans and Aspergillus fumigatus. Inflammation was promoted by PAR 1 and …
activated receptors (PARs), a family of G-protein-coupled receptors. We report here that
activation of Toll-like receptors (TLRs) by fungi unmasks an essential and divergent role for
PAR 1 and PAR 2 in downstream signaling and inflammation. TLRs activated PARs and
triggered distinct signal transduction pathways involved in inflammation and immunity to
Candida albicans and Aspergillus fumigatus. Inflammation was promoted by PAR 1 and …