Regulation of tissue factor gene expression in the monocyte procoagulant response to endotoxin
SA Gregory, JH Morrissey… - Molecular and cellular …, 1989 - Am Soc Microbiol
SA Gregory, JH Morrissey, TS Edgington
Molecular and cellular biology, 1989•Am Soc MicrobiolTissue factor is the cellular receptor and cofactor for plasma factor Vila which initiates the
coagulation protease cascade on cell surfaces. Although normally absent from all
intravascular cell types, tissue factor can be induced to appear on circulating monocytes and
vascular endothelial cells by specific inflammatory or immunological mediators. In this study,
we have examined the regulation of endotoxin-induced tissue factor gene expression in
peripheral blood monocytes.
coagulation protease cascade on cell surfaces. Although normally absent from all
intravascular cell types, tissue factor can be induced to appear on circulating monocytes and
vascular endothelial cells by specific inflammatory or immunological mediators. In this study,
we have examined the regulation of endotoxin-induced tissue factor gene expression in
peripheral blood monocytes.
Abstract
Tissue factor is the cellular receptor and cofactor for plasma factor Vila which initiates the coagulation protease cascade on cell surfaces. Although normally absent from all intravascular cell types, tissue factor can be induced to appear on circulating monocytes and vascular endothelial cells by specific inflammatory or immunological mediators. In this study, we have examined the regulation of endotoxin-induced tissue factor gene expression in peripheral blood monocytes.
American Society for Microbiology