Elevated levels of tumor necrosis factor alpha and mortality in centenarians
H Bruunsgaard, K Andersen-Ranberg… - The American journal of …, 2003 - Elsevier
BACKGROUND: Aging is accompanied by low-grade inflammation. Tumor necrosis factor
(TNF) α initiates the cytokine cascade, and high levels are associated with dementia and
atherosclerosis in persons aged 100 years. We hypothesized that TNF-α was also a
prognostic marker for all-cause mortality in these persons. METHODS: We enrolled 126
subjects at or around the time of their 100th birthday. Plasma levels of TNF-α, interleukin (IL)-
6, IL-8, and C-reactive protein were measured at baseline, and we determined the …
(TNF) α initiates the cytokine cascade, and high levels are associated with dementia and
atherosclerosis in persons aged 100 years. We hypothesized that TNF-α was also a
prognostic marker for all-cause mortality in these persons. METHODS: We enrolled 126
subjects at or around the time of their 100th birthday. Plasma levels of TNF-α, interleukin (IL)-
6, IL-8, and C-reactive protein were measured at baseline, and we determined the …
