The interplay of selective and homeostatic processes dominates the behavior of B lineage
subsets following B cell antigen receptor (BCR) expression, and extends to determinants of
immune response quality and the persistence of immunologic memory. A key concept
emerging from these considerations is that primary events acting upstream of mature B
lymphocyte pools can profoundly impact downstream populations as the system attempts
homeostatic adjustments. Since, advancing age is accompanied by profound changes in B …