Loss of CD28 expression on T lymphocytes: a marker of replicative senescence
RB Effros - Developmental & comparative immunology, 1997 - Elsevier
The CD28 molecule, a disulfide-linked homodimer expressed on peripheral T cells and
thymocytes, mediates an essential costimulatory signal following engagement of the T cell
receptor (TCR). Increased proportions of CD28—T cells have been observed during aging
and in situations of chronic immune stimulation, but the origin and functional characteristics
of these cells have been unclear. T cells which reach replicative senescence in culture after
multiple rounds of cell division have shortened telomeres, respond poorly to stress stimuli …
thymocytes, mediates an essential costimulatory signal following engagement of the T cell
receptor (TCR). Increased proportions of CD28—T cells have been observed during aging
and in situations of chronic immune stimulation, but the origin and functional characteristics
of these cells have been unclear. T cells which reach replicative senescence in culture after
multiple rounds of cell division have shortened telomeres, respond poorly to stress stimuli …