[HTML][HTML] The reduced expression of surrogate light chains in B cell precursors from senescent BALB/c mice is associated with decreased E2A proteins
EM Sherwood, W Xu, AM King, BB Blomberg… - Mechanisms of ageing …, 2000 - Elsevier
Senescent mice exhibit decreased numbers of pre-B cells in the bone marrow. Herein, we
show that the molecules, λ5 and VpreB, which comprise the surrogate light chain component
of the pre-B cell receptor, are reduced in pro-B/early pre-B cells derived in vitro from the
bone marrow of 18–27 months old BALB/c mice after stimulation with IL-7. Both λ5 and
VpreB expression were decreased at the mRNA level as indicated by semi-quantitative RT-
PCR; this suggests that the reduced surrogate light chains seen in senescent B cell …
show that the molecules, λ5 and VpreB, which comprise the surrogate light chain component
of the pre-B cell receptor, are reduced in pro-B/early pre-B cells derived in vitro from the
bone marrow of 18–27 months old BALB/c mice after stimulation with IL-7. Both λ5 and
VpreB expression were decreased at the mRNA level as indicated by semi-quantitative RT-
PCR; this suggests that the reduced surrogate light chains seen in senescent B cell …