This study examines the alteration of oligodendrocyte progenitor cells which express
membrane NG2 chondroitin sulfate proteoglycan after focal ischemia in the rat brain. Adult
male Sprague–Dawley rats were subjected to 90 min occlusion of the middle cerebral artery,
followed by reperfusion time of up to 2 weeks. The distribution and morphological changes
in NG2-positive oligodendrocyte progenitor cells were immunohistochemically examined.
Stellate-shaped NG2-positive cells with multiple branched processes were detected in both …