[HTML][HTML] Nitric oxide modulates oxygen sensing by hypoxia-inducible factor 1-dependent induction of prolyl hydroxylase 2
U Berchner-Pfannschmidt, H Yamac, B Trinidad… - Journal of biological …, 2007 - ASBMB
The transcription factor complex hypoxia-inducible factor 1 (HIF-1) plays a crucial role in
cellular adaptation to low oxygen availability. O 2-dependent HIF prolyl hydroxylases
(PHDs) modify HIF-1α, which is sent to proteasomal degradation under normoxia. Reduced
activity of PHDs under hypoxia allows stabilization of HIF-1α and induction of HIF-1 target
gene expression. Like hypoxia, nitric oxide (NO) was found to inhibit normoxic PHD activity
leading to HIF-1α accumulation. In contrast under hypoxia, NO reduced HIF-1α levels due to …
cellular adaptation to low oxygen availability. O 2-dependent HIF prolyl hydroxylases
(PHDs) modify HIF-1α, which is sent to proteasomal degradation under normoxia. Reduced
activity of PHDs under hypoxia allows stabilization of HIF-1α and induction of HIF-1 target
gene expression. Like hypoxia, nitric oxide (NO) was found to inhibit normoxic PHD activity
leading to HIF-1α accumulation. In contrast under hypoxia, NO reduced HIF-1α levels due to …
