[HTML][HTML] Dysregulated ryanodine receptors mediate cellular toxicity: restoration of normal phenotype by FKBP12. 6
CH George, GV Higgs, JJ Mackrill, FA Lai - Journal of biological chemistry, 2003 - ASBMB
Ca 2+ homeostasis is a vital cellular control mechanism in which Ca 2+ release from
intracellular stores plays a central role. Ryanodine receptor (RyR)-mediated Ca 2+ release
is a key modulator of Ca 2+ homeostasis, and the defective regulation of RyR is pathogenic.
However, the molecular events underlying RyR-mediated pathology remain undefined.
Cells stably expressing recombinant human RyR2 (Chinese hamster ovary cells, CHO
hRyR2) had similar resting cytoplasmic Ca 2+ levels ([Ca 2+] c) to wild-type CHO cells (CHO …
intracellular stores plays a central role. Ryanodine receptor (RyR)-mediated Ca 2+ release
is a key modulator of Ca 2+ homeostasis, and the defective regulation of RyR is pathogenic.
However, the molecular events underlying RyR-mediated pathology remain undefined.
Cells stably expressing recombinant human RyR2 (Chinese hamster ovary cells, CHO
hRyR2) had similar resting cytoplasmic Ca 2+ levels ([Ca 2+] c) to wild-type CHO cells (CHO …
