Expression of hMTH1 in the hippocampi of control and Alzheimer's disease
A Furuta, T Iida, Y Nakabeppu, T Iwaki - Neuroreport, 2001 - journals.lww.com
The oxidized purine nucleoside triphosphatase, hMTH1, has a critical role towards
preventing errors caused by oxidized purine nucleoside triphosphates such as 8-oxo-dGTP
and 2-hydroxy-dATP. We investigated the immunohistochemical expression of hMTH1 in
human hippocampal postmortem tissues representing non-neurological disease and
Alzheimer's disease (AD). In the non-neurological subjects the hMTH1 protein was enriched
in the stratum lucidum at CA3 corresponding to mossy fiber synapses. In AD subjects, the …
preventing errors caused by oxidized purine nucleoside triphosphates such as 8-oxo-dGTP
and 2-hydroxy-dATP. We investigated the immunohistochemical expression of hMTH1 in
human hippocampal postmortem tissues representing non-neurological disease and
Alzheimer's disease (AD). In the non-neurological subjects the hMTH1 protein was enriched
in the stratum lucidum at CA3 corresponding to mossy fiber synapses. In AD subjects, the …
