[HTML][HTML] Anti-apoptotic molecule Bcl-2 regulates the differentiation, activation, and survival of both osteoblasts and osteoclasts
Y Nagase, M Iwasawa, T Akiyama, Y Kadono… - Journal of biological …, 2009 - ASBMB
The anti-apoptotic molecule Bcl-2 inhibits apoptosis by preventing cytochrome c release
from mitochondria. Although several studies have indicated the importance of Bcl-2 in
maintaining skeletal integrity, the detailed cellular and molecular mechanisms remain
elusive. Bcl-2−/− mice are growth-retarded and exhibit increased bone volume of the
primary spongiosa, mainly due to the decreased number and dysfunction of osteoclasts.
Osteoblast function is also impaired in Bcl-2−/− mice. Ex vivo studies on osteoblasts and …
from mitochondria. Although several studies have indicated the importance of Bcl-2 in
maintaining skeletal integrity, the detailed cellular and molecular mechanisms remain
elusive. Bcl-2−/− mice are growth-retarded and exhibit increased bone volume of the
primary spongiosa, mainly due to the decreased number and dysfunction of osteoclasts.
Osteoblast function is also impaired in Bcl-2−/− mice. Ex vivo studies on osteoblasts and …