[HTML][HTML] Interplay of Ca2+ and cAMP Signaling in the Insulin-secreting MIN6 β-Cell Line*[boxs]
LR Landa, M Harbeck, K Kaihara, O Chepurny… - Journal of Biological …, 2005 - ASBMB
Ca 2+ and cAMP are important second messengers that regulate multiple cellular
processes. Although previous studies have suggested direct interactions between Ca 2+
and cAMP signaling pathways, the underlying mechanisms remain unresolved. In particular,
direct evidence for Ca 2+-regulated cAMP production in living cells is incomplete.
Genetically encoded fluorescence resonance energy transfer-based biosensors have made
possible real-time imaging of spatial and temporal gradients of intracellular cAMP …
processes. Although previous studies have suggested direct interactions between Ca 2+
and cAMP signaling pathways, the underlying mechanisms remain unresolved. In particular,
direct evidence for Ca 2+-regulated cAMP production in living cells is incomplete.
Genetically encoded fluorescence resonance energy transfer-based biosensors have made
possible real-time imaging of spatial and temporal gradients of intracellular cAMP …