Perilipin A is the most abundant phosphoprotein on adipocyte lipid droplets and is essential
for lipid storage and lipolysis. Perilipin null mice exhibit diminished adipose tissue, elevated
basal lipolysis, reduced catecholamine-stimulated lipolysis, and increased insulin
resistance. To understand the physiological consequences of increased perilipin expression
in vivo, we generated transgenic mice that overexpressed either human or mouse perilipin
using the adipocyte-specific aP2 promoter/enhancer. Phenotypes of female transgenic and …