[HTML][HTML] Overexpression of perilipin A and B blocks the ability of tumor necrosis factor α to increase lipolysis in 3T3-L1 adipocytes
SC Souza, LM de Vargas, MT Yamamoto, P Lien… - Journal of Biological …, 1998 - ASBMB
Perilipins, a family of phosphoproteins, are specifically located at the surface of intracellular
lipid (triacylglycerol) droplets, the site of lipolysis. Stimulation of lipolysis in 3T3-L1
adipocytes by tumor necrosis factor α (TNF-α) is associated with a decrease in total cellular
expression of perilipin A and B, consistent with the hypothesis that a decrease in perilipin
protein expression is required for TNF-α-induced lipolysis. Adenovirus-mediated
overexpression of perilipin A or B maintains perilipin protein levels on the lipid droplet and …
lipid (triacylglycerol) droplets, the site of lipolysis. Stimulation of lipolysis in 3T3-L1
adipocytes by tumor necrosis factor α (TNF-α) is associated with a decrease in total cellular
expression of perilipin A and B, consistent with the hypothesis that a decrease in perilipin
protein expression is required for TNF-α-induced lipolysis. Adenovirus-mediated
overexpression of perilipin A or B maintains perilipin protein levels on the lipid droplet and …