[HTML][HTML] Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and-independent mechanisms
H Miyoshi, SC Souza, HH Zhang, KJ Strissel… - Journal of Biological …, 2006 - ASBMB
Hormone-sensitive lipase (HSL) is the predominant lipase effector of catecholamine-
stimulated lipolysis in adipocytes. HSL-dependent lipolysis in response to catecholamines is
mediated by protein kinase A (PKA)-dependent phosphorylation of perilipin A (Peri A), an
essential lipid droplet (LD)-associated protein. It is believed that perilipin phosphorylation is
essential for the translocation of HSL from the cytosol to the LD, a key event in stimulated
lipolysis. Using adipocytes retrovirally engineered from murine embryonic fibroblasts of …
stimulated lipolysis in adipocytes. HSL-dependent lipolysis in response to catecholamines is
mediated by protein kinase A (PKA)-dependent phosphorylation of perilipin A (Peri A), an
essential lipid droplet (LD)-associated protein. It is believed that perilipin phosphorylation is
essential for the translocation of HSL from the cytosol to the LD, a key event in stimulated
lipolysis. Using adipocytes retrovirally engineered from murine embryonic fibroblasts of …