[HTML][HTML] Spatiotemporal regulation of ERK2 by dual specificity phosphatases
CJ Caunt, SP Armstrong, CA Rivers… - Journal of Biological …, 2008 - ASBMB
Although many stimuli activate extracellular signal-regulated kinases 1 and 2 (ERK1/2), the
kinetics and compartmentalization of ERK1/2 signals are stimulus-dependent and dictate
physiological consequences. ERKs can be inactivated by dual specificity phosphatases
(DUSPs), notably the MAPK phosphatases (MKPs) and atypical DUSPs, that can both
dephosphorylate and scaffold ERK1/2. Using a cell imaging model (based on knockdown of
endogenous ERKs and add-back of wild-type or mutated ERK2-GFP reporters), we explored …
kinetics and compartmentalization of ERK1/2 signals are stimulus-dependent and dictate
physiological consequences. ERKs can be inactivated by dual specificity phosphatases
(DUSPs), notably the MAPK phosphatases (MKPs) and atypical DUSPs, that can both
dephosphorylate and scaffold ERK1/2. Using a cell imaging model (based on knockdown of
endogenous ERKs and add-back of wild-type or mutated ERK2-GFP reporters), we explored …
