Angiogenesis in the mouse retina: a model system for experimental manipulation

A Uemura, S Kusuhara, H Katsuta… - Experimental cell research, 2006 - Elsevier
A Uemura, S Kusuhara, H Katsuta, SI Nishikawa
Experimental cell research, 2006Elsevier
The vascular system of the mouse retina provides a useful model for analyzing the
molecular and cellular mechanisms regulating angiogenesis because (1) hierarchical
vascular networks are newly formed only after birth,(2) the cellular components involved in
angiogenesis are well characterized, and (3) all the processes are accessible for monitoring
and manipulation. In this article, we present an overview of our current understanding of the
process of retinal angiogenesis and describe a number of methodologies applicable to …
The vascular system of the mouse retina provides a useful model for analyzing the molecular and cellular mechanisms regulating angiogenesis because (1) hierarchical vascular networks are newly formed only after birth, (2) the cellular components involved in angiogenesis are well characterized, and (3) all the processes are accessible for monitoring and manipulation. In this article, we present an overview of our current understanding of the process of retinal angiogenesis and describe a number of methodologies applicable to experimental manipulation of the retinal vascular system.
Elsevier