[HTML][HTML] TNFR1 Promotes Tumor Necrosis Factor-mediated Mouse Colon Epithelial Cell Survival through RAF Activation of NF-κB∗
Tumor necrosis factor (TNF) is a therapeutic target in the treatment of inflammatory bowel
disease; however, the exact role of TNF signaling in the colon epithelium remains unclear.
We demonstrate that TNF activation of TNF receptor (R) 1 stimulates both pro-and anti-
apoptotic signaling pathways in the colon epithelium; however, TNFR1 protects against
colon epithelial cell apoptosis following TNF exposure. To investigate anti-apoptotic
signaling pathways downstream of TNFR1, we generated an intestinal epithelium-specific …
disease; however, the exact role of TNF signaling in the colon epithelium remains unclear.
We demonstrate that TNF activation of TNF receptor (R) 1 stimulates both pro-and anti-
apoptotic signaling pathways in the colon epithelium; however, TNFR1 protects against
colon epithelial cell apoptosis following TNF exposure. To investigate anti-apoptotic
signaling pathways downstream of TNFR1, we generated an intestinal epithelium-specific …
