Principles of the role of dendritic cells in immunity 3. Overview on the role of chemokines and their receptors in DC biology 3.1. Selective use of chemokines to direct migration at distinct stages of the DC life cycle 3.2. Tissue-specific DC recruitment by distinct chemokines 3.3. Role of DC-derived chemokines in T helper-subtype differentiation 4. Distinct chemokine-chemokine receptor interactions relevant in DC biology 4.1. Role of CXCR4/CXCL12 (SDF-1) in egress of DC precursors from the BM into the blood 4.2. Role of CCR2/CCL2 (MCP-1) in recruitment of DC precursors into inflamed tissue 4.3. Role of CCR2/CCL2 (MCP-1) in recruitment of DC involved in innate immunity 4.4. Role of CCR1, CCR5, CCR6, CCR8 and CCR9 in DC recruitment and migration 4.5. CX3CR1-mediated effects on DCs

4.6. CCL19 (ELC, MIP-3beta) and CCL21-mediated effects on DCs via CCR7 4.7. Effect of CCL17 (TARC) and CCL22 (MDC) produced by DCs on T cells via CCR4 4.8. Effect of CXCL9 (MIG), CXCL10 (IP10) and CXCL11 (ITAC) produced by DCs on Th1 cells via CXCR3 5. Viral exploitation of chemokines receptors expressed by DCs 6. Concluding remarks