[HTML][HTML] Prenatal transplantation of cytokine-stimulated marrow improves early chimerism in a resistant strain combination but results in poor long-term engraftment
OBJECTIVE: In the absence of immunodeficiency, only microchimerism (< 0.1%) has been
achieved in human fetal recipients or nonhuman primates following in utero hematopoietic
cell transplantation (IUHCT). We hypothesized that enhanced long-term engraftment might
be more reliably achieved in microchimeric systems if higher levels of chimerism existed
during development of adaptive immunity. To evaluate this hypothesis, we stimulated the
donor cells with vascular endothelial growth factor (VEGF) and stem cell factor (SCF) prior to …
achieved in human fetal recipients or nonhuman primates following in utero hematopoietic
cell transplantation (IUHCT). We hypothesized that enhanced long-term engraftment might
be more reliably achieved in microchimeric systems if higher levels of chimerism existed
during development of adaptive immunity. To evaluate this hypothesis, we stimulated the
donor cells with vascular endothelial growth factor (VEGF) and stem cell factor (SCF) prior to …