Efficacy of lytic peptide-bound magnetite nanoparticles in destroying breast cancer cells
CSSR Kumar, C Leuschner, EE Doomes… - … of nanoscience and …, 2004 - ingentaconnect.com
CSSR Kumar, C Leuschner, EE Doomes, L Henry, M Juban, J Hormes
Journal of nanoscience and nanotechnology, 2004•ingentaconnect.comA 23-amino-acid synthetic lytic peptide (Hecate) was covalently linked to magnetite
nanoparticles and the lytic peptide-bound nanoparticles were characterized by X-ray
absorption near-edge structure spectroscopy, transmission electron microscopy, and
electron diffraction. Investigation of magnetic properties with a superconducting quantum
interference device (SQUID) magnetometer has shown a reduction in the saturation
magnetization (Ms) of magnetite nanoparticles after binding with lytic peptide. An in vitro cell …
nanoparticles and the lytic peptide-bound nanoparticles were characterized by X-ray
absorption near-edge structure spectroscopy, transmission electron microscopy, and
electron diffraction. Investigation of magnetic properties with a superconducting quantum
interference device (SQUID) magnetometer has shown a reduction in the saturation
magnetization (Ms) of magnetite nanoparticles after binding with lytic peptide. An in vitro cell …
A 23-amino-acid synthetic lytic peptide (Hecate) was covalently linked to magnetite nanoparticles and the lytic peptide-bound nanoparticles were characterized by X-ray absorption near-edge structure spectroscopy, transmission electron microscopy, and electron diffraction. Investigation of magnetic properties with a superconducting quantum interference device (SQUID) magnetometer has shown a reduction in the saturation magnetization (Ms) of magnetite nanoparticles after binding with lytic peptide. An in vitro cell culture assay with breast cancer cell lines MDA-MB-435S revealed that the lytic peptide-bound magnetite nanoparticles were therapeutically active.
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