Reversal of Iron Deficiency Anemia after Helicobacter pylori Eradication in Patients with Asymptomatic Gastritis
B Annibale, M Marignani, B Monarca… - Annals of internal …, 1999 - acpjournals.org
B Annibale, M Marignani, B Monarca, G Antonelli, A Marcheggiano, G Martino, F Mandelli…
Annals of internal medicine, 1999•acpjournals.orgBackground: Iron deficiency anemia is the most common form of anemia worldwide. Recent
studies have suggested an association between Helicobacter pylori infection and iron
deficiency. Objective: To investigate the effects of eradicating H. pylori with combination
antibiotic therapy on iron deficiency anemia in patients with H. pylori-associated gastritis.
Design: Case series. Setting: University hospital. Patients: 30 patients with a long history of
iron deficiency anemia in whom H. pylori-associated gastritis was the only pathologic …
studies have suggested an association between Helicobacter pylori infection and iron
deficiency. Objective: To investigate the effects of eradicating H. pylori with combination
antibiotic therapy on iron deficiency anemia in patients with H. pylori-associated gastritis.
Design: Case series. Setting: University hospital. Patients: 30 patients with a long history of
iron deficiency anemia in whom H. pylori-associated gastritis was the only pathologic …
Background
Iron deficiency anemia is the most common form of anemia worldwide. Recent studies have suggested an association between Helicobacter pylori infection and iron deficiency.
Objective
To investigate the effects of eradicating H. pylori with combination antibiotic therapy on iron deficiency anemia in patients with H. pylori-associated gastritis.
Design
Case series.
Setting
University hospital.
Patients
30 patients with a long history of iron deficiency anemia in whom H. pylori-associated gastritis was the only pathologic gastrointestinal finding detected.
Intervention
Eradication therapy with two antibiotics and discontinuation of iron replacement therapy.
Measurements
Complete blood count, ferritin levels, and gastroscopy with biopsy to evaluate H. pylori status.
Results
At 6 months, 75% of patients had recovered from anemia (P < 0.001), ferritin values increased from 5.7 ± 0.7 µg/L to 24.5 ± 5.2 µg/L (95% CI, 8.85 to 29.97). After 12 months, 91.7% of patients had recovered from anemia.
Conclusions
Cure of H. pylori infection is associated with reversal of iron dependence and recovery from iron deficiency anemia.
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