Ethanol consumption impairs regulation of fatty acid metabolism by decreasing the activity of AMP-activated protein kinase in rat liver
J García-Villafranca, A Guillén, J Castro - Biochimie, 2008 - Elsevier
The mechanisms by which ethanol consumption causes accumulation of hepatic
triacylglycerols are complex. AMP-activated protein kinase (AMPK) plays a central role in the
regulation of lipid metabolism. Therefore, in the present study we investigated whether
AMPK may have a role in the development of ethanol-induced fatty liver. Hepatocytes
isolated from rats fed with an ethanol-containing liquid diet showed higher rates of fatty acid
and triacylglycerol syntheses, but a decreased rate of fatty acid oxidation, concomitant to a …
triacylglycerols are complex. AMP-activated protein kinase (AMPK) plays a central role in the
regulation of lipid metabolism. Therefore, in the present study we investigated whether
AMPK may have a role in the development of ethanol-induced fatty liver. Hepatocytes
isolated from rats fed with an ethanol-containing liquid diet showed higher rates of fatty acid
and triacylglycerol syntheses, but a decreased rate of fatty acid oxidation, concomitant to a …