Introduction 3. AMPK structure and activation 4. AMPK regulation of cellular energetics 5. AMPK and transcription 5.1. AMPK and regulation of epigenetic processes 5.1. 1. Histone 3 (H3)

5.1. 2. p300/CREB binding protein (CBP) 5.1. 3. RNA polymerase I (Pol I) 5.2. AMPK and transcriptional regulation of cellular growth and differentiation 5.2. 1. p53

5.2. 2. Thyroid receptor interacting protein 6 (TRIP6) 5.3. AMPK and transcriptional regulation of skeletal muscle metabolism 5.3. 1. Histone deacetylase 5 (HDAC5) 5.3. 2. GLUT4 enhancer factor (GEF) 5.3. 3. Nuclear respiratory factor 1 (NRF-1) 5.4. AMPK and transcriptional regulation of hepatic metabolism 5.4. 1. Transducer of regulated CREB activity 2 (TORC2) 5.4. 2. AICAR response element binding protein (AREBP) 5.4. 3. Carbohydrate response element binding protein (ChREBP) 5.4. 4. Hepatocyte nuclear factor 4a (HNF4a) 5.5. Other metabolic transcriptional targets 5.5. 1. Peroxisime proliferator activated receptor a (PPARa) 6. Perspectives