[HTML][HTML] Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) …
SC Burgess, TC Leone, AR Wende, MA Croce… - Journal of Biological …, 2006 - ASBMB
The peroxisome proliferator-activated receptor γ (PPARγ) coactivator 1α (PGC-1α) is a
highly inducible transcriptional coactivator implicated in the coordinate regulation of genes
encoding enzymes involved in hepatic fatty acid oxidation, oxidative phosphorylation, and
gluconeogenesis. The present study sought to assess the effects of chronic PGC-1α
deficiency on metabolic flux through the hepatic gluconeogenic, fatty acid oxidation, and
tricarboxylic acid cycle pathways. To this end, hepatic metabolism was assessed in wild-type …
highly inducible transcriptional coactivator implicated in the coordinate regulation of genes
encoding enzymes involved in hepatic fatty acid oxidation, oxidative phosphorylation, and
gluconeogenesis. The present study sought to assess the effects of chronic PGC-1α
deficiency on metabolic flux through the hepatic gluconeogenic, fatty acid oxidation, and
tricarboxylic acid cycle pathways. To this end, hepatic metabolism was assessed in wild-type …