[HTML][HTML] Differential regulation of sterol regulatory element-binding protein 1c transcriptional activity by insulin and liver X receptor during liver development
A Bobard, I Hainault, P Ferré, F Foufelle… - Journal of Biological …, 2005 - ASBMB
Sterol regulatory element-binding proteins (SREBPs) are transcription factors involved in the
synthesis of cholesterol and fatty acids. In adults, the isoform SREBP-1c is the predominant
transcript in the liver of fed animals, and it activates triglyceride production from glucose
when diet is enriched in carbohydrates. Studies have shown that SREBP-1c expression is
dependent on insulin but also on the availability of oxysterols, ligands of the nuclear liver X
receptor (LXR). The aim of this study was to investigate the regulation of the hepatic SREBP …
synthesis of cholesterol and fatty acids. In adults, the isoform SREBP-1c is the predominant
transcript in the liver of fed animals, and it activates triglyceride production from glucose
when diet is enriched in carbohydrates. Studies have shown that SREBP-1c expression is
dependent on insulin but also on the availability of oxysterols, ligands of the nuclear liver X
receptor (LXR). The aim of this study was to investigate the regulation of the hepatic SREBP …