Mcl-1 overexpression in hepatocellular carcinoma: a potential target for antisense therapy
W Sieghart, D Losert, S Strommer, D Cejka… - Journal of …, 2006 - Elsevier
BACKGROUND/AIMS: Recently, the anti-apoptotic Mcl-1 protein has been reported as a
resistance factor in various types of cancer. Here we investigated the presence of Mcl-1
protein in hepatocellular carcinoma (HCC) tissues and its potential role as a molecular drug
target for HCC therapy. METHODS: HCC specimens of 149 patients were examined by
immunohistochemistry for Mcl-1 expression. Antisense oligonucleotides (ASO) targeting Mcl-
1 were evaluated as monotherapy and in combination with cisplatin in the HCC cell lines …
resistance factor in various types of cancer. Here we investigated the presence of Mcl-1
protein in hepatocellular carcinoma (HCC) tissues and its potential role as a molecular drug
target for HCC therapy. METHODS: HCC specimens of 149 patients were examined by
immunohistochemistry for Mcl-1 expression. Antisense oligonucleotides (ASO) targeting Mcl-
1 were evaluated as monotherapy and in combination with cisplatin in the HCC cell lines …