Resistin, central obesity, and type 2 diabetes

CL McTernan, PG McTernan, AL Harte, PL Levick… - The Lancet, 2002 - thelancet.com
CL McTernan, PG McTernan, AL Harte, PL Levick, AH Barnett, S Kumar
The Lancet, 2002thelancet.com
Resistin, an adipocyte-derived cytokine, causes insulin resistance and glucose intolerance
in mice. We investigated whether resistin expression was higher in human abdominal
adipose tissue than other adipose tissue depots. We extracted RNA from 32 adipose tissue
samples (13 subcutaneous abdominal, seven omentum, six thigh, and six breast).
Quantitative PCR was used to determine resistin mRNA expression. Resistin mRNA
concentrations were similar in both the subcutaneous abdominal and omental depots. The …
Summary
Resistin, an adipocyte-derived cytokine, causes insulin resistance and glucose intolerance in mice. We investigated whether resistin expression was higher in human abdominal adipose tissue than other adipose tissue depots. We extracted RNA from 32 adipose tissue samples (13 subcutaneous abdominal, seven omentum, six thigh, and six breast). Quantitative PCR was used to determine resistin mRNA expression. Resistin mRNA concentrations were similar in both the subcutaneous abdominal and omental depots. The abdominal depots showed a 418% increase in resistin mRNA expression compared with the thigh. Increased resistin expression in abdominal fat could explain the increased risk of type 2 diabetes associated with central obesity.
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