[HTML][HTML] Heterotetramers of human liver mitochondrial (class 2) aldehyde dehydrogenase expressed in Escherichia coli: a model to study the heterotetramers …
X Wang, S Sheikh, D Saigal, L Robinson… - Journal of Biological …, 1996 - ASBMB
About 50% of the Oriental population have less liver mitochondrial aldehyde
dehydrogenase (ALDH2) activity than do other people. It was found that they possessed an
enzyme with a lysine at position 487 (E487K) instead of glutamate (Glu 487). We previously
found that the K m for NAD of recombinant human and rat E487K enzymes increased more
than 150-fold (Farrés, J., Wang X., Takahashi, K., Cunningham, SJ, Wang, TT, and Weiner, H
(1994) J. Biol. Chem. 269, 13854-13860). Many aldehyde dehydrogenase-deficient people …
dehydrogenase (ALDH2) activity than do other people. It was found that they possessed an
enzyme with a lysine at position 487 (E487K) instead of glutamate (Glu 487). We previously
found that the K m for NAD of recombinant human and rat E487K enzymes increased more
than 150-fold (Farrés, J., Wang X., Takahashi, K., Cunningham, SJ, Wang, TT, and Weiner, H
(1994) J. Biol. Chem. 269, 13854-13860). Many aldehyde dehydrogenase-deficient people …