[HTML][HTML] Targeted inhibition of Ca2+/calmodulin-dependent protein kinase II in cardiac longitudinal sarcoplasmic reticulum results in decreased phospholamban …
Y Ji, B Li, TD Reed, JN Lorenz, MA Kaetzel… - Journal of Biological …, 2003 - ASBMB
To investigate the role of Ca 2+/calmodulin-dependent kinase II in cardiac sarcoplasmic
reticulum function, transgenic mice were designed and generated to target the expression of
a Ca 2+/calmodulin-dependent kinase II inhibitory peptide in cardiac longitudinal
sarcoplasmic reticulum using a truncated phospholamban transmembrane domain. The
expressed inhibitory peptide was highly concentrated in cardiac sarcoplasmic reticulum.
This resulted in a 59.7 and 73.6% decrease in phospholamban phosphorylation at threonine …
reticulum function, transgenic mice were designed and generated to target the expression of
a Ca 2+/calmodulin-dependent kinase II inhibitory peptide in cardiac longitudinal
sarcoplasmic reticulum using a truncated phospholamban transmembrane domain. The
expressed inhibitory peptide was highly concentrated in cardiac sarcoplasmic reticulum.
This resulted in a 59.7 and 73.6% decrease in phospholamban phosphorylation at threonine …