In chronic nephropathies prolonged ACE inhibition can induce remission: dynamics of time-dependent changes in GFR
P RUGGENENTI, A PERNA, R BENINI… - Journal of the …, 1999 - journals.lww.com
Abstract The Ramipril Efficacy in Nephropathy Core and Follow-Up Study found that≥ 36
mo of continued ramipril therapy decreased substantially the risk of end-stage renal failure
(ESRF) in patients with chronic nephropathies and a urinary protein excretion rate≥ 3 g/24
h. This study investigates the time-dependent changes in GFR in these patients and in
control subjects who were randomized to conventional therapy during the Core period and
switched to ramipril during the Follow-Up study. Analyses included 150 patients (continued …
mo of continued ramipril therapy decreased substantially the risk of end-stage renal failure
(ESRF) in patients with chronic nephropathies and a urinary protein excretion rate≥ 3 g/24
h. This study investigates the time-dependent changes in GFR in these patients and in
control subjects who were randomized to conventional therapy during the Core period and
switched to ramipril during the Follow-Up study. Analyses included 150 patients (continued …