Prognostic value of angiotensin-I converting enzyme I/D polymorphism for nephropathy in type 1 diabetes mellitus: a prospective study
S Hadjadj, R Belloum, B Bouhanick… - Journal of the …, 2001 - journals.lww.com
Angiotensin-I converting enzyme (ACE) regulates renal hemodynamics. Its insertion/deletion
(I/D) polymorphism, which determines most of ACE interindividual variance, was proposed
as a genetic marker for diabetic nephropathy. A substitution (M235T) polymorphism in
angiotensinogen (AGT) may interact with ACE I/D polymorphism for the risk of diabetic
nephropathy, but their prognostic values have to be established by follow-up studies. A total
of 310 type 1 diabetes mellitus patients who attended the diabetic clinic in Angers (France) …
(I/D) polymorphism, which determines most of ACE interindividual variance, was proposed
as a genetic marker for diabetic nephropathy. A substitution (M235T) polymorphism in
angiotensinogen (AGT) may interact with ACE I/D polymorphism for the risk of diabetic
nephropathy, but their prognostic values have to be established by follow-up studies. A total
of 310 type 1 diabetes mellitus patients who attended the diabetic clinic in Angers (France) …