A simple method of estimating progression of chronic renal failure

WE Mitch, M Walser, GA Buffington, J Lemann Jr - The Lancet, 1976 - Elsevier
WE Mitch, M Walser, GA Buffington, J Lemann Jr
The Lancet, 1976Elsevier
In 31 of 34 patients with chronic renal insufficiency caused by various diseases, reciprocal
serum-creatinine concentration declined linearly as creatinine concentration rose from a
mean of 2· 6 mg/dl to 14· 8 mg/dl over an average of 71 months. These results indicate that
in most cases reciprocal serum-creatinine declines linearly with time as chronic renal failure
progresses. Analysis of this relation in individual patients gives an estimate of the
progression of the disease, may help to determine the effects of therapy, and could be used …
Abstract
In 31 of 34 patients with chronic renal insufficiency caused by various diseases, reciprocal serum-creatinine concentration declined linearly as creatinine concentration rose from a mean of 2·6 mg/dl to 14·8 mg/dl over an average of 71 months. These results indicate that in most cases reciprocal serum-creatinine declines linearly with time as chronic renal failure progresses. Analysis of this relation in individual patients gives an estimate of the progression of the disease, may help to determine the effects of therapy, and could be used to predict when dialysis will become necessary.
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